Professional biomass harvesting tubular centrifugal separator manufacturers

Introduction Cell separation or harvesting is the first step towards downstream bioprocess and is required for the recovery of either extra- or intracellular products. A few different equipments can be found in industrial practices, and centrifuges are among the most commonly used in fermentation applications. Conventional centrifuges are a widely chosen option. In fact, being commonplace in laboratories, the relative ease of use and other advantages such as temperature control and variable speed make them a great choice, mainly for small-scale processes. The volume of the bucket is usually a limitation for this type of centrifuge [1]. For larger scales, continuous centrifuges have been the instrument of choice. The tubular-cylinder continuous centrifuges, in particular, are separation instruments characterized by their ability to process many times the capacity of their cylinder total volume without interruption. This characteristic results from a design that allows continuous feeding of a solid-liquid mixture while simultaneously expelling the liquid component. In a typical bioprocess application, the solid, which is retained in the cylinder, is the cell mass. Clarified liquid is obtained from an exit port while the machine is running. Cell mass is taken from the tubular cylinder after the machine is stopped. A removable plastic cylinder liner is often used to simplify cell paste removal.