The application prospect of tubular centrifuges in bacterial cell separation

Advantages

Good separation effect: It can generate a strong centrifugal force field, which has a remarkable separation effect on bacteria in fermentation broth with low concentration, fine solid particles, and small density difference between solid and liquid. It can obtain wet bacteria with low water content, tight and dense texture, and the centrifugal supernatant can reach a high degree of clarity. For example, it performs excellently in the separation of Escherichia coli, lactic acid bacteria, etc.

Wide application range: It can be used for the separation of various types of bacteria, including those related to vaccines such as DPT vaccine and rabies vaccine in vaccine preparation, as well as Bacillus and spore - forming bacteria in the field of biopharmaceuticals.

Great potential for equipment improvement: With the development of technology, tubular centrifuges are constantly being improved and upgraded. For example, the adoption of microcomputer - controlled digital display, lower - damping grease - free lubrication systems, etc. not only solves the problem of material contamination by grease but also improves the automation level and stability of the equipment.

Development Trends

Integration with other technologies: In the future, more attention may be paid to the coupling with other related technologies. For example, it may be combined with technologies such as filtration and membrane separation to form an integrated separation process, so as to improve separation efficiency and product quality and better meet different production requirements.

Intelligence and automation: It will further develop in the direction of intelligence and automation. By equipping advanced sensors and control systems, real - time monitoring and automatic adjustment of the separation process can be achieved, reducing manual operation, improving production efficiency and consistency, and reducing labor intensity and human errors.

Special functions such as low - temperature separation: For some bacteria sensitive to temperature, low - temperature separation can be achieved by selecting cooling coils and other methods, which can better protect the activity of bacteria and product quality and meet more special process requirements.

However, tubular centrifuges also have certain limitations. For example, the single - machine production capacity is small, and it is suitable for materials with a solid content of less than 5%. It has a poor separation effect on materials with a high solid content. Moreover, during the operation of the equipment, the labor intensity is high, it can only operate intermittently, the operation requirements are high, and the safety risks are relatively large. But overall, with continuous improvement and coordinated development with other technologies, tubular centrifuges will still have an important application prospect in the field of bacterial cell separation, especially in industries with high requirements for separation accuracy and product quality, such as biopharmaceuticals and food industries.

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